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Literature summary for 3.1.3.9 extracted from

  • Csala, M.; Margittai, E.; Senesi, S.; Gamberucci, A.; Banhegyi, G.; Mandl, J.; Benedetti, A.
    Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallate (2007), FEBS Lett., 581, 1693-1698.
    View publication on PubMed
Search for more literature for 3.1.3.9

Inhibitors

Inhibitors Comment Organism Structure
D-glucose reduces the G6Pase activity both in intact and permeabilized liver microsomes in a concentration-dependent manner. Extent of inhibition is comparable with that achieved by epigallocatechin gallate in intact microsomes Rattus norvegicus
epicatechin gallate acts similarly but less efficiently than epigallocatechin gallate Rattus norvegicus
epigallocatechin gallate increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes. It does not hinder microsomal D-glucose 6-phosphate uptake. Reduces activity of G6Pase through the inhibition of glucose efflux from the endoplasmic reticulum lumen; inhibition of enzyme in intact, but not in permeabilized microsome. Epigallocatechin gallate does not hinder microsomal glucose uptake, but inhibits microsomal glucose efflux thus inhibiting the enzyme through an elevated luminal glucose level Rattus norvegicus
gallocatechin gallate increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes Rattus norvegicus
additional information propyl gallate has no effect Rattus norvegicus
S3483 only depresses G6Pase activity in intact microsomes, thus increases latency Rattus norvegicus
vanadate reduces activity both in intact and permeabilized microsomes and decreases latency Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver microsome Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
47.5
-
 intact microsome, presence of 0.1 mM epigallocatechin gallate Rattus norvegicus
80
-
 intact microsome Rattus norvegicus
107
-
 permeabilized microsome, presence of 0.1 mM epigallocatechin gallate Rattus norvegicus
124
-
 permeabilized microsome Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Rattus norvegicus D-glucose + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G6Pase
-
 Rattus norvegicus
glucose 6-phosphatase
-
 Rattus norvegicus